A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk.

Previous prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-standardized vitamin D concentration were estimated using multivariable-adjusted conditional logistic regression. 25(OH)D concentration was positively associated with risk for total prostate cancer (multivariable-adjusted OR comparing highest vs. lowest study-specific fifth was 1.22; 95% confidence interval, 1.13-1.31; P trend < 0.001). However, this association varied by disease aggressiveness (P heterogeneity = 0.014); higher circulating 25(OH)D was associated with a higher risk of nonaggressive disease (OR per 80 percentile increase = 1.24, 1.13-1.36) but not with aggressive disease (defined as stage 4, metastases, or prostate cancer death, 0.95, 0.78-1.15). 1,25(OH)2D concentration was not associated with risk for prostate cancer overall or by tumor characteristics. The absence of an association of vitamin D with aggressive disease does not support the hypothesis that vitamin D deficiency increases prostate cancer risk. Rather, the association of high circulating 25(OH)D concentration with a higher risk of nonaggressive prostate cancer may be influenced by detection bias. SIGNIFICANCE: This international collaboration comprises the largest prospective study on blood vitamin D and prostate cancer risk and shows no association with aggressive disease but some evidence of a higher risk of nonaggressive disease

Review: Cooperative group trials — Southwest Oncology Group (SWOG) innovations in advanced prostate cancer

The major goals of the Southwest oncology genitourinary (SWOG-GU) committee in the area of advanced prostate cancer are to improve the survival and quality of life (QOL) of patients with advanced prostate cancer. SWOG trials have examined the role of combined androgen blockade, intermittent androgen deprivation, and the early application of chemotherapy in castration-naïve disease. In addition, they have contributed to advancing the current chemotherapy standard of docetaxel plus prednisone, and ongoing trials seek to improve upon that standard. Finally, surrogate endpoints have been identified and markers of treatment response or resistance with novel technology are under active investigation. This review highlights findings from recent SWOG clinical trials for advanced prostate cancer, emphasizing the clinical impact and future applications of the data

Serum Oxidized Protein and Prostate Cancer Risk within the Prostate Cancer Prevention Trial

Overall view of the three tower complex and white connecting base, looking south from the US 1 (Brickell Ave.) bridge; Located on the south side of the Miami River in Downtown's northern Brickell Financial District. The complex consists of three skyscrapers and the Icon Brickell Plaza, connecting the towers at their base. The first two towers, the Icon Brickell North Tower and South Tower, are twin buildings.The third phase of the complex is the Viceroy Tower (Viceroy Hotel, a "condo-hotel"), which is 500 feet (150 m) tall with 50 floors. In total there are 1,800 units (1,648 residential, 162 hotel). Arriving guests are greeted by a spectacular two story entrance, lined with 100 columns throughout the driveway, some with lit “eyes” that glow to guide your way and “watch over each arriving guest.” The gigantic columns, estimated at 5 million dollars, are modeled to resemble Moai Statues of Easter Island heads that embrace your journey into Starck’s world of playful spirit. Source: Wikipedia; http://en.wikipedia.org/wiki/Main_Page (accessed 9/4/2015